LB915 Occupational and environmental triggers of atopic dermatitis

Atopic dermatitis (AD) prevalence varies greatly across nations, particularly Northern/Southern hemispheres, wealthier/developing countries. While genetics undoubtfully play an important role, this geographic variation may also be influenced by the living environment and socioeconomic factors.We aimed to assess association between AD, environmental sociodemographic characteristics in Canada. A cross-sectional case control study was performed using CanPath data(Canadian Partnership for Tomorrow’s Health), largest prospective Canadian populational cohort. total of 32,087 patients with self-reported diagnosis AD 1:1 age-sex matched controls were included.Patients linked CANUE (Canadian Urban Environmental Health Research Consortium) database based on place residence (6-digit postal codes)to factors interest including air pollutants(NO2, PM2.5, O3, SO2), annual average temperature, precipitation,walkability index (dwelling intersection density), nighttime light brightness. Social stratifiers included material social deprivation indices, education level income. Student’s t-test continuous variables Chi-Square proportions. significantly more likely exposed higher concentrations pollutants, NO2 (p= 0.0014), PM2.5 0.0038), SO2 (p=0.0114), O3 (p <0.0001). Higher brightness <0.0001) lower walkability (measured dwelling densities(p<0.0001))were seen AD. associated class (lower level, but not income), temperature (p< 0.0001).Climatic (e.g. colder climate), pollution, neighborhood determinants health predispose development Better understanding external risk is reduce inequity improve disease prevention management.